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October 1978

Disulfiram Neuropathy

Author Affiliations

From the University of Toronto, Toronto Western, and St Michael's Hospitals.

Arch Neurol. 1978;35(10):658-660. doi:10.1001/archneur.1978.00500340034006

• A 35-year-old man developed a distal sensorimotor polyneuropathy after taking disulfiram, 500 mg daily for five months. His symptoms improved after the drug therapy was discontinued. Clinical, electrophysiological, and pathological observations during the acute stage and during recovery suggest that disulfiram produces a distal axonopathy.

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