• Gamma-aminobutyric acid (GABA) was measured by the ion-exchange fluorometric method in CSF from 22 individuals at risk for Huntington's disease (HD), six individuals with HD, and five neurologically normal controls. The mean (± SD) GABA level in the specimens from patients with HD was 142 ± 27 pmoles/ ml, whereas that of the normal control specimens was 297 ± 87 pmoles/ml. The mean GABA level of the specimens from the individuals at risk for HD was 209 ± 79 pmoles/ml; however, nine of these were in the normal range with a mean value of 281 ± 72 pmoles/ml, while the other 13 were below the normal range with a mean value of 159 ± 27 pmoles/ ml. The data indicate that low GABA levels in CSF are evident prior to the onset of symptoms of HD but a predictive value can only be determined by continued observation of the clinical course of these at-risk individuals.
Manyam NVB, Hare TA, Katz L, Glaeser BS. Huntington's Disease: Cerebrospinal Fluid GABA Levels in At-risk Individuals. Arch Neurol. 1978;35(11):728–730. doi:10.1001/archneur.1978.00500350032006
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