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November 1978

Pineal Tumors: A 53-Year Experience

Author Affiliations

From the Departments of Neurology (Drs Donat, Gomez, and Reagan), Pathology and Anatomy (Drs Okazaki and Reagan), Diagnostic Radiology (Dr Baker), and Neurologic Surgery (Dr Laws), Mayo Clinic and Mayo Foundation, Rochester, Minn.

Arch Neurol. 1978;35(11):736-740. doi:10.1001/archneur.1978.00500350040008

• Thirty-four patients with pathologically confirmed primary pineal tumors were evaluated at the Mayo Clinic from 1923 through 1976. AH tumors were of germ cell or pineal cell origin. Most patients were adolescent boys with subacute increased intracranial pressure and Parinaud's syndrome. Hypothalamic symptoms were surprisingly infrequent. Direct surgical intervention was associated with high mortality, but has been more successful in recent years.