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November 1978

Peripheral Neuropathy in Myotonic Dystrophy: Relation to Glucose Intolerance

Author Affiliations

From the Section of Endocrinology and Metabolism, Department of Medicine (Drs Olson and Nuttall), and the Department of Physical Medicine and Rehabilitation (Drs Olson, Jou, and Quast), Veterans Administration Hospital, and the University of Minnesota (Drs Quast and Nuttall), Minneapolis. Dr Jou is now at the Rehabilitation Hospital of the Pacific, Honolulu; Dr Olson is now at the Kaiser Foundation Hospital, Redwood City, Calif.

Arch Neurol. 1978;35(11):741-745. doi:10.1001/archneur.1978.00500350045009

• Motor nerve conduction velocity (MNCV) was measured in three peripheral nerves in each of 24 patients with myotonic dystrophy having various degrees of associated glucose intolerance and was compared with results in a control group. Both groups had similar glucose tolerance and were matched for age and adiposity. The mean MNCV in the ulnar, median, and peroneal nerves in the myotonic dystrophy group were all significantly slowed (P <.01). This peripheral nerve dysfunction, usually subclinical, is yet another manifestation of this multisystem disease and is unrelated to the associated glucose intolerance.

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