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November 1978

Thermolability in Wernicke's Encephalopathy

Author Affiliations

From the Departments of Neurology (Drs Lipton, Payne, and Rosenberg), Physiology (Drs Lipton and Rosenberg), and Internal Medicine (Dr Garza), Southwestern Medical School, University of Texas Health Science Center, Dallas.

Arch Neurol. 1978;35(11):750-753. doi:10.1001/archneur.1978.00500350054011

• A patient with signs of Wernicke's disease had low body temperature and showed thermolability when challenged with cold and heat. This man expressed no feelings of thermal discomfort about his persistently low core temperature or about induced changes in his core temperature. He also showed abnormalities in his febrile response to pyrogen and in his circadian temperature rhythm. Treatment with thiamine hydrochloride resulted in substantial improvement in these thermoregulatory deficits.

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