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November 1978

Varicella and Acute Cerebellar Ataxia

Author Affiliations

From the Departments of Neurology (Dr Peters), Neuropathology (Dr Bots), and Pathology (Dr Lindeman) and the Laboratory of Medical Microbiology (Dr Versteeg), State University, Academic Hospital, Leiden, The Netherlands.

Arch Neurol. 1978;35(11):769-771. doi:10.1001/archneur.1978.00500350073016

• In two cases of varicella-associated cerebellar ataxia, varicella-zoster antigens in CSF cells were shown by an indirect immunofluorescent technique. Direct viral invasion in CNS disease complicating varicella plays an important part in pathogenesis and rules out a single immune-mediated mechanism.