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November 1978

Clonazepam in Treatment of Absence Seizures With Automatisms

Author Affiliations

Dept of Pediatrics Columbus Children's Hospital Div Neurol Ohio State Univ School of Med 931 Chatham Lane Columbus, OH 43221

Arch Neurol. 1978;35(11):773-774. doi:10.1001/archneur.1978.00500350077022

To the Editor.—  Clonazepam (Clonopin), as indicated in the package insert, is not currently recommended in the United States for use in partial seizures with complex symptomatology, although there are a number of articles suggesting that it may be useful in this type of seizure disorder.1-9 The following are two case reports of children with very frequent absence seizures with automatisms who had no response to other anticonvulsants but had very dramatic and sustained seizure control with clonazepam alone.

Report of Cases.—  Case 1.—A 9-year-old girl had a 11/2-year history of uncontrolled seizures. History, family history, development, physical examination, neurological examination, intelligence, detailed workup, including computerized axial tomography and bilateral selective carotid arteriography were all normal. Clinically, her seizures consisted of absence attacks lasting ten to 60 seconds, which were often accompanied by such automatisms as picking movements with her hands or chewing movements. These occurred ten to 20

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