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December 1978

Effect of an Opiate Antagonist on Movement Disorders

Author Affiliations

From the Experimental Therapeutics Branch, Intramural Research Program, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, Md.

Arch Neurol. 1978;35(12):810-811. doi:10.1001/archneur.1978.00500360034006

• Animal experiments suggest that opiate peptides might play a role in extrapyramidal function. This hypothesis was tested by administering the opiate antagonist, naltrexone, in doses sufficient to antagonize exogenous opiates, to patients with parkinsonism and Huntington's disease. No improvement in the clinical features of either disorder was noted.

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