[Skip to Navigation]
January 1979

Neoplastic Angioendotheliosis: The Case of the Missed Primary?

Author Affiliations

From the Departments of Pathology and Medicine, Vancouver General Hospital, Shaughnessy Hospital, and the University of British Columbia, Vancouver.

Arch Neurol. 1979;36(1):5-7. doi:10.1001/archneur.1979.00500370035004

• Two patients are described, of whom one suffered from progressive dementia, the other with a picture suggestive of Guillain-Barré syndrome. Both were found at necropsy to have small vessels throughout the body clogged with malignant cells with resultant cerebral infarcts. The source in one case was a 1-cm tumor in the thyroid, in the other a microscopic focus in the pancreas. It is suggested that most cases described as neoplastic angioendotheliosis involving the brain represent vascular dissemination of an unrecognized primary carcinoma rather than a miraculously widespread malignant endothelial transformation.