• Two patients are described, of whom one suffered from progressive dementia, the other with a picture suggestive of Guillain-Barré syndrome. Both were found at necropsy to have small vessels throughout the body clogged with malignant cells with resultant cerebral infarcts. The source in one case was a 1-cm tumor in the thyroid, in the other a microscopic focus in the pancreas. It is suggested that most cases described as neoplastic angioendotheliosis involving the brain represent vascular dissemination of an unrecognized primary carcinoma rather than a miraculously widespread malignant endothelial transformation.
Dolman CL, Sweeney VP, Magil A. Neoplastic Angioendotheliosis: The Case of the Missed Primary? Arch Neurol. 1979;36(1):5–7. doi:10.1001/archneur.1979.00500370035004
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