• In 1952, Cogan introduced the term "congenital ocular motor apraxia" (COA) to describe an abnormality of eye movements characterized by absent or defective voluntary horizontal gaze. Since his original description, there have been few subsequent reports of this disorder. A ten-year review of clinical records from the University of Wisconsin Hospitals disclosed eight patients with COA. In two patients subjected to neuroradiologic testing, agenesis of the corpus callosum was detected. Voluntary horizontal gaze appears to be a learned phenomenon, and defective interhemispheric transfer of visual information may be important in the pathogenesis of COA.
Orrison WW, Robertson WC. Congenital Ocular Motor Apraxia: A Possible Disconnection Syndrome. Arch Neurol. 1979;36(1):29–31. doi:10.1001/archneur.1979.00500370059013
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.