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January 1979

Postanoxic Action Myoclonus (Lance-Adams Syndrome) Responding to Valproate

Author Affiliations

From the Department of Neurology, Bowman Gray School of Medicine, Winston-Salem, NC (Dr Rollinson), and the Alfred Hospital, Melbourne (Dr Gilligan). Dr Rollinson is now with the Department of Neurology, Vanderbilt University, Nashville, Tenn.

Arch Neurol. 1979;36(1):44-45. doi:10.1001/archneur.1979.00500370074019

• A patient with postanoxic action myoclonus (Lance-Adams syndrome) was severely disabled with this movement disorder. Valproate sodium was administered orally, with complete resolution of the myoclonus. This favorable response has been maintained for two years. Excessive yawning, the only side effect encountered, was dose related and was abolished with the addition of pimozide to the drug regimen.