To the Editor.—
I was interested to read the article on cerebral malaria in the Archives (35:271-275, 1978). I was surprised that there was no mention of the effect of blood sludging on the brain circulation that occurs in malaria as described by Knisely et al1 that outlines some of the mechanical factors involved in brain damage with malaria. Experimental findings of Knisely et al coincide with our therapeutic findings on the beneficial effects of anticoagulant therapy in senile and presenile dementia.2It strikes me that further research along these lines would be very useful in that from a therapeutic point of view, the use of anticoagulant therapy might prevent cerebral damage and even death resulting from malaria.
Walsh AC. Cerebral Malaria. Arch Neurol. 1979;36(2):119. doi:10.1001/archneur.1979.00500380089019
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