To the Editor.—
Creutzfeldt-Jakob disease has been rarely reported below the 37th parallel,1 with very few cases from Latin America and Argentina. We report three cases diagnosed within a three-year period in a Community Hospital in Argentina. To our knowledge, there have been only six other cases reported from Argentina since 1945.2-4Diagnosis was made mainly on the basis of typical pathologic findings on CNS tissue obtained either by biopsy or autopsy. Additional support was obtained from EEG, clinical findings and evolution, neuroradiologic and laboratory studies.
Report of Cases.—
Case 1.—A 75-year-old woman had a one-month history of gait disturbance, mental deterioration, and right-sided hemiparesis. Symptoms steadily evolved to a full-blown dementia with incontinence, generalized seizures, and myoclonus. She died three months after clinical onset. All studies were noncontributory except the EEG, which showed disorganization and superimposed triphasic waves. Biopsy and autopsy material confirmed the diagnosis (Figure).
Nogueira G, Sundblad A, Gomez-Molina O. Creutzfeldt-Jakob Disease in Argentina. Arch Neurol. 1979;36(3):181. doi:10.1001/archneur.1979.00500390099021
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