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April 1979

Leukomalacia With Ruptured Saccular Aneurysm

Author Affiliations

From the Department of Pathology, Downstate Medical Center, Brooklyn, NY.

Arch Neurol. 1979;36(4):231-232. doi:10.1001/archneur.1979.00500400085015

• A 42-year-old woman with a ruptured saccular aneurysm of the internal carotid artery developed large areas of cerebral leukomalacia, resulting in hemiparesis and an obtunded mental state. A significant factor in the development of the white matter lesions was episodic hypotension, leading to reduced cerebral blood flow in a patient whose cerebral circulation was already compromised by vasospasm secondary to the subarachnoid hemorrhage. This case illustrates yet another clinical situation associated with the development of white matter necrosis.

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