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April 1979

Hemiparkinsonism: A Human Model for Studying Dopaminergic Supersensitivity

Author Affiliations

From the Departments of Pharmacology (Dr Trabucchi) and Neurology (Drs Albizzati, Frattola, and Scarlato), University of Milan.

Arch Neurol. 1979;36(4):246-248. doi:10.1001/archneur.1979.00500400100020

• The observation of a patient suffering from a parkinsonian syndrome, almost entirely expressed on the right side, and "on-off" attacks with rotatory movement of the trunk, led us to consider that the rotational model of animals may be reproduced in man. The symptoms presented by our patient may reflect a predominant degeneration in the nigrostriatal pathway of the left side. We suggest that his torsion behavior is due to hypersensitivity phenomenon of the dopaminergic receptors on this side.