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May 1979

Huntington's Chorea and Bromocriptine

Author Affiliations

Neurology Clinic University of Genoa Via de Toni, 5 16132 Genoa, Italy

Arch Neurol. 1979;36(5):322. doi:10.1001/archneur.1979.00500410100024

To the Editor.—  We read with interest the letter from Frattola et al (35:60, 1978) about the mechanisms of action of bromocriptine in Huntington's chorea. According to the authors, bromocriptine should be considered as a partial dopaminergic agonist, with a "biphasic effect" that depends on the dosage.Similar effects have been observed by us after the administration of bromocriptine to 11 patients affected by Huntington's chorea1: involuntary movements showed a good improvement when the daily dosage of bromocriptine was low (< 40 mg/day), whereas a slight worsening was seen after the administration of higher dosages (40 to 60 mg/day). Moreover, CSF HVA levels substantially increased after the low-dosage treatment with bromocriptine, and substantially decreased when a high dosage was used.These data, namely, the increase in CSF HVA levels associated with the clinical improvement of choreic movements, suggest that dopamine-sensitive receptors in the neostriatum are blocked, from a low

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