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May 1979

Familial Occurrence of Entrapment Neuropathies

Author Affiliations

Department of Neurology
Department of Orthopedics University Hospital Limoges, France

Arch Neurol. 1979;36(5):323. doi:10.1001/archneur.1979.00500410101026

To the Editor.—  We read with interest the letter by E. W. Massey, MD,1 in the March 1978 issue of the Archives, which pointed out the familial occurrence of meralgia paraesthetica. It seems that other entrapment neuropathies, such as carpal tunnel syndrome, can also be familial.We recently reviewed the case of a 53-year-old woman complaining of nocturnal numbness and tingling in the hands. Both carpel tunnels were decompressed surgically, and the symptoms were alleviated. At operation, the median nerves were seen to be constricted under thickened transverse carpal ligaments. Later it was discovered that the patient's father had similar bilateral signs with weakness and wasting of the abductor pollicis brevis muscles. At operation, the same constrictions as in the daughter's case were found. Ultrastructural examination of the ligaments showed collagenous connective tissue without any evidence of amyloid.The reports of Rukavina et al2 and Malhoudji et