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June 1979

History of Occlusive Cerebrovascular Disease: I. From Wepfer to Moniz

Author Affiliations

From the Department of Neurosurgery, Wayne State University School of Medicine (E. S. Gurdjian, MD) and Harper-Grace Hospitals (Edwin S. Gurdjian, MD), Detroit.

Arch Neurol. 1979;36(6):340-343. doi:10.1001/archneur.1979.00500420050004

• Occlusive cerebrovascular disease of carotid and vertebral arteries was described by Wepfer in 1658 and by Willis in 1665. Wepfer thought apoplexy resulted from occlusive disease of the vessels. Willis described collateral channels between these vessels, which prevented the development of stroke.

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