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June 1979

Multicentric Glioma: A Diagnostic Problem

Author Affiliations

Department of Neurology University Hospital of Jacksonville Jacksonville, FL 32209

Arch Neurol. 1979;36(6):388. doi:10.1001/archneur.1979.00500420098021

To the Editor.—  Multiple intracerebral masses demonstrated by arteriography, radionuclide scan, or computerized tomography (CT) are often considered to be metastatic lesions. We report the case of a woman with a breast mass where CT demonstrated two separate lesions that were primary multicentric gliomas.

Report of a Case.—  A 56-year-old woman was admitted to the University Hospital of Jacksonville, Fla, shortly after two episodes of weakness and paresthesias of the left arm and leg. Examination revealed only a mass in the right breast. The results of a neurologic examination were normal. A CT showed two separate, low-density cerebral lesions that were enhanced by contrast. A presumptive diagnosis of metastatic carcinoma was made. A biopsy specimen of the breast mass showed fibrocystic disease. An extensive search for a primary neoplasm was negative. The CSF protein concentration was 150 mg/dL, and the CSF glucose level and cell count were normal. Cultures were