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August 1979

Dibutyryl Cyclic Adenosine 3',5'-Monophosphate: Its Role in Regulation of Cat Brain Extracellular Fluid

Author Affiliations

From the Department of Neurosurgery, The Johns Hopkins University School of Medicine and Hospital, Baltimore, Md.

Arch Neurol. 1979;36(8):498-500. doi:10.1001/archneur.1979.00500440068012

• The role of dibutyryl cyclic adenosine 3',5'-monophosphate (db cAMP) in influencing the water content of the cat's gray and white matter was evaluated by intracortical injection of 20 μL of 2 x 10-1 to 2 x 10-6M solution of db cAMP. Cholera toxin, a stimulator of adenylate cyclase, also was tested. Concentrations of db cAMP less than 10-3M failed to produce significant change in brain water content, while concentrations greater than 10-2M produced 31.5% ± 8% and 17.3% ± 3.6% increases in white matter volume, respectively (P <.05). Cholera toxin did not increase brain water levels. These results are discussed in relation to the pathophysiology of brain edema.

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