• A previously healthy 20-year-old woman died of a progressive cerebral disease that involved the brain stem and the cerebral hemispheres successively. The illness ran its course in 80 days. Postmortem examination showed a multifocal necrotizing encephalopathy that chiefly affected gray matter structures and that was mainly located in the brain stem and cerebral cortex. The cause and pathogenesis remain unknown.
Safdari H, Richardson EP. Subacute Necrotizing Polioencephalopathy. Arch Neurol. 1979;36(10):638–642. doi:10.1001/archneur.1979.00500460072011
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