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October 1979

Subacute Necrotizing Polioencephalopathy

Author Affiliations

From the C. S. Kubik Laboratory for Neuropathology, James Homer Wright Pathology Laboratories, Massachusetts General Hospital and the Department of Neurology-Neuropathology, Harvard Medical School, Boston.

Arch Neurol. 1979;36(10):638-642. doi:10.1001/archneur.1979.00500460072011

• A previously healthy 20-year-old woman died of a progressive cerebral disease that involved the brain stem and the cerebral hemispheres successively. The illness ran its course in 80 days. Postmortem examination showed a multifocal necrotizing encephalopathy that chiefly affected gray matter structures and that was mainly located in the brain stem and cerebral cortex. The cause and pathogenesis remain unknown.