• A patient with severe narcolepsy and cataplexy had been treated with a high dosage of methylphenidate hydrochloride, but the drug was not effective. To relieve the patient's cardiac arrhythmia, which was assumed to be secondary to drug therapy, we withdrew methylphenidate therapy and started propranolol hydrochloride therapy. When the dosage of propranolol was increased to a level consistent with maximum β-adrenergic receptor blockade, the attacks were eliminated.
Kales A, Cadieux R, Soldatos CR, Tan T. Successful Treatment of Narcolepsy With Propranolol: A Case Report. Arch Neurol. 1979;36(10):650–651. doi:10.1001/archneur.1979.00500460084015
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