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November 1979

Biphasic Periodic Paralysis

Author Affiliations

From the Department of Neurology (Drs Chesson and Peters) and Division of Neuropathology (Dr Schochet), University of Texas Medical Branch, Galveston. Dr Chesson is now with the Department of Neurology, Louisiana State University Medical Center, Shreveport.

Arch Neurol. 1979;36(11):700-704. doi:10.1001/archneur.1979.00500470070014

• A young man with episodes characteristic of familial normokalemic periodic paralysis was restudied after a change in the nature of his attacks. He now has spontaneously occurring and provokable episodes of both hyperkalemic and hypokalemic periodic paralyses that are superimposed on a persistent myopathy. Hypokalemia seems to be associated with facilitated entry of glucose and potassium into muscles, whereas resistance to glucose and potassium entry accompanies hyperkalemia. The possibility that episodes of both hypokalemic and hyperkalemic weaknesses can occur in one person should be considered in pathogenic postulates regarding periodic paralysis.