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November 1979

Quadriparesis and Nuclear Oculomotor Palsy With Total Bilateral Ptosis Mimicking Coma: A Mesencephalic 'Locked-in Syndrome'?

Author Affiliations

From the Neurological Department, University of Berne, Switzerland.

Arch Neurol. 1979;36(11):708-710. doi:10.1001/archneur.1979.00500470078016

• Upper lid and vertical eye movements are usually preserved in patients with the "locked-in" syndrome, a condition manifested by anarthria, spastic quadriparesis, and intact mental function, and caused by lesions in the ventral portion of the pons. We describe a presumed mesencephalic "locked-in" syndrome in a patient who had total bilateral ptosis at the onset of his disease and later on experienced complete bilateral oculomotor nerve paralysis.