This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.
To the Editor.—
In the February 1977 Archives (34:114-115, 1977), we described an infant who had severe generalized congenital hypotonia, in whom selective myosin degeneration was found in a muscle biopsy specimen. During the following year, we reexamined the girl and performed another biopsy on her contralateral quadriceps femoris muscle. We would like to report here the benign course of this disorder.During the second year of life, the infant showed great improvement in motor performance. At 1 year of age, she was able to stand against the wall and walk with assistance. At 15 months of age, she learned to roll over and to sit up. At 18 months of age, she was able to get up from the floor and walk unassisted. At 27 months of age, she still had a positive Gowers' maneuver and tired easily. The results of a Bayley development test showed a two-month delay
Shapira Y, Yarom R. Congenital Hypotonia due to Myosin Degeneration. Arch Neurol. 1979;36(11):727. doi:10.1001/archneur.1979.00500470097026
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: