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November 1979

Cerebral Reticulum Cell Sarcoma

Author Affiliations

Neurological Department St Joseph Hospital Eindhoven The Netherlands
Pathological Anatomical Institute University Hospital Nijmegen The Netherlands

Arch Neurol. 1979;36(11):727. doi:10.1001/archneur.1979.00500470097027

To the Editor.—  Williams et al described in the Archives (36:206-210, 1979) two patients with cerebral reticulum cell sarcoma (CRCS) with remissions for eight months and seven years, respectively, following therapy with corticosteroids. These authors mentioned that in exceptional case reports a more prolonged clinical course is described.We draw your attention to a case history of a 43-year-old patient with a primary reticulum cell of the brain who has survived 61/2 years. This patient was treated with intrathecal methotrexate injections every four to six weeks over a period of 41/2 years. This tumor was localized in the fornix and led to intermittent cell eruptions in the CSF. The exceptionally long survival period and the therapy with intrathecal methotrexate, hardly mentioned in the literature, are the reasons for this comment.

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