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December 1979

Phenytoin and Carbamazepine in Production of Cleft Palates in Mice: Comparison of Teratogenic Effects

Author Affiliations

From the College of Dentistry (Dr R. Paulson and Mr Jreissaty) and the Department of Neurology (Dr G. Paulson), Ohio State University, and Riverside Methodist Hospital (Dr W. Paulson), Columbus.

Arch Neurol. 1979;36(13):832-836. doi:10.1001/archneur.1979.00500490046007

• The teratogenic activity of two anticonvulsant drugs, phenytoin sodium and carbamazepine, was studied in pregnant mice fed phenytoin and carbamazepine during days 8 to 13. Incidence of palatal defects and other abnormalities correlated with increasing dosages and blood levels of the drugs. Phenytoin produced a much higher incidence of teratogenic effects than carbamazepine.