• The teratogenic activity of two anticonvulsant drugs, phenytoin sodium and carbamazepine, was studied in pregnant mice fed phenytoin and carbamazepine during days 8 to 13. Incidence of palatal defects and other abnormalities correlated with increasing dosages and blood levels of the drugs. Phenytoin produced a much higher incidence of teratogenic effects than carbamazepine.
Paulson RB, Paulson GW, Jreissaty S. Phenytoin and Carbamazepine in Production of Cleft Palates in Mice: Comparison of Teratogenic Effects. Arch Neurol. 1979;36(13):832–836. doi:10.1001/archneur.1979.00500490046007
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