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January 1980

Cholinomimetics and Memory: The Effect of Choline Chloride

Author Affiliations

From the Stanford (Calif) University School of Medicine, and the Veterans Administration Hospital, Palo Alto, Calif (Drs Tinklenberg, Hollister, Pfefferbaum, and Kopell); the Mount Sinai School of Medicine, and the Psychiatry Service, Bronx VA Hospital, New York (Drs Davis and Mohs).

Arch Neurol. 1980;37(1):49-52. doi:10.1001/archneur.1980.00500500079013

• Young normal subjects received 16 g of choline chloride in a double-blind A-B-A design. Short- and long-term memory function was evaluated. Comparison of group means indicated that choline chloride did not significantly affect shortterm memory or long-term memory. However, individual subjects may have had some aspects of long-term memory affected by choline chloride treatments. The results suggest that the effect of lower doses of choline on long-term memory should be evaluated.

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