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April 1980

Modified Snake Venom in Amyotrophic Lateral SclerosisLack of Clinical Effectiveness

Author Affiliations

From the Departments of Neurology (Drs Rivera and Hines; Ms Breitbach), Physical Medicine (Dr Grabois), and Medicine (Dr Deaton), Baylor College of Medicine and the Neurosensory Center, the Methodist Hospital, Houston.

Arch Neurol. 1980;37(4):201-203. doi:10.1001/archneur.1980.00500530039003

• Diverse observations including neurological examination, manual muscle testing, quantitative electromyography, videotape esophagrams, and pulmonary function tests were used in a double-blind study evaluating the use of detoxified snake venoms as modified neurotoxin in 64 patients with amyotrophic lateral sclerosis (ALS) treated for six months. Transient periods of improvement were more common in the patients who received placebo. This study did not demonstrate any benefit from administration of modified snake venom to patients with ALS.