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April 1980

Amyloid Neuropathy and Tremor in Waldenström's Macroglobulinemia

Author Affiliations

From the Departments of Medicine (Dr Mastaand Pathology (Dr Bajada), University of Australia, Perth, and the Department of Neu logy (Drs Mastaglia and Fisher), Sir Charles Gairdner Hospital, Queen Elizabeth II Medical Centre, Nedlands, Western Australia.

Arch Neurol. 1980;37(4):240-242. doi:10.1001/archneur.1980.00500530078014

• We report a case of Waldenström's macroglobulinemia with amyloid neuropathy and a parkinsonian syndrome. We describe the light and electron microscopic findings in a sural nerve biopsy specimen and discuss the possible pathogenic mechanisms in the production of the neuropathy. In contrast to a number of previous cases of neuropathy associated with Waldenström's macroglobulinemia, evidence of immunoglobulin deposition on nerve fibers was not found using immunofluorescent techniques.

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