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May 1980

Epidural Spinal Cord Compression in Acute Myelogenous Leukemia

Author Affiliations

From the Departments of Medicine (Drs Hildebrand and Leenaerts), Neurosurgery (Dr Nubourgh), and Pathology (Dr Verhest), Institut Jules Bordet, and the Department of Neuropathology (Dr Flament-Durand), University of Brussels, Belgium.

Arch Neurol. 1980;37(5):319. doi:10.1001/archneur.1980.00500540097021

To the best of our knowledge, epidural accumulation of neoplastic tissue has not been described in patients with acute myelogenous leukemia (AML). Therefore, we would like to report the following observation to stress the possibility of this unusual complication and thereby to allow its diagnosis at an early stage when radiotherapy may effect cure.

REPORT OF A CASE  A 25-year old man was admitted to the Jules Bordet Institute, Brussels, because of rapidly progressing paraplegia and complete loss of sphincter control. Six months before, the patient was found to have an acute myelogenous leukemia. A complete remission was achieved after a two-month treatment combining adriamycin, vincristine sulfate, and cytosine-arabinoside. Neither prophylactic CNS-irradiation nor intrathecal chemotherapy were given. The patient was receiving 6-mercaptopurine, methotrexate, daunorubicin hydrochloride, and vincristine when neurological signs appeared.Symptoms of spinal cord compression, which consisted of gait difficulties, started one week before admission. One month before admission

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