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May 1980

Haloperidol for Nonkinesiogenic Paroxysmal Dyskinesia

Author Affiliations

Department of Neurology University of Michigan Medical School Ann Arbor, MI 48109

Arch Neurol. 1980;37(5):325-326. doi:10.1001/archneur.1980.00500540103027

To the Editor.—  The report of Goodenough et al,1 which reviewed the familial and acquired paroxysmal dyskinesias, states that anticonvulsants and other drugs are seldom effective in the rare nonkinesiogenic form of this disorder. We have recently treated a brother and sister who had nonkinesiogenic paroxysmal dyskinesia with carbamazepine and haloperidol, and the results so far are encouraging.

Report of Cases.—CASE 1.—  A 19-year-old man had attacks of stiffness and shaking of his legs for ten months. He first felt his toes curling, and then his legs stiffened and shook for 15 to 30 minutes. There was no weakness or altered consciousness, but he could not stand during an attack. The attacks occurred monthly and were unrelated to heavy exercise, movement, food, or alcohol. Phenytoin sodium made his symptoms worse, but 0.5 mg of haloperidol at bedtime has controlled the attacks for eight months.

CASE 2.  The 13-year-old sister

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