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May 1980

Oculogyric Crisis and Carbamazepine

Author Affiliations

Clinical Drug Safety Department Geigy Pharmaceuticals Summit, NJ 07901

Arch Neurol. 1980;37(5):326. doi:10.1001/archneur.1980.00500540104030

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To the Editor.—  Reference is made to the report by Dr Berchou (Archives 36:522-523, 1979) concerning a case of oculogyric crisis occurring in association with carbamazepine (Tegretol) therapy. In our discussion with Dr Berchou prior to his published report, we noted that oculomotor disturbances are listed in our package insert for carbamazepine as possible adverse reactions. The clinical findings described by Dr Berchou would be included under that classification. Those oculomotor disturbances that have been reported seem to be related to dosage, and usually are controlled by titration of carbamazepine to the minimum effective dose level.

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