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June 1980

Human Schwann Cells in Tissue Culture Histochemical and Ultrastructural Studies

Author Affiliations

From the National Institute of Arthritis, Metabolism, and Digestive Diseases and the National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Md.

Arch Neurol. 1980;37(6):329-337. doi:10.1001/archneur.1980.00500550031001

• Schwann cells cultures were established from 40 human peripheral nerves that underwent biopsy according to an explant-reexplantation technique that markedly reduces non-Schwann cells and achieves cultures greatly enriched in Schwann cells suitable for a wide range of studies. Described are the growth characteristics and histochemical, ultrastructural, and ultrastructural-cytochemical patterns of normal human cultured Schwann cells from 12 patients with dysneuronal neuropathies or with no demonstrable peripheral nerve abnormality. These findings serve as a basis of comparison when seeking abnormalities of Schwann cells grown from peripheral nerves of patients with putative dysschwannian neuropathies.

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