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June 1980

Levels of γ-Aminobutyric Acid in Cerebrospinal Fluid in Various Neurologic Disorders

Author Affiliations

From the Neurology Service, Veterans Administration Medical and Regional Office Center, Wilmington, Del (Drs Manyam and Katz), and the Departments of Neurology (Drs Manyam and Katz) and Pharmacology (Drs Hare, Gerber, and Grossman), Jefferson Medical College of Thomas Jefferson University, Philadelphia.

Arch Neurol. 1980;37(6):352-355. doi:10.1001/archneur.1980.00500550054006

• Levels of γ-aminobutyric acid (GABA) in CSF were measured by the ion exchange-fluorometric method in 136 patients who underwent evaluation for neurologic disorders. In 19 patients with no organic neurologic or mental disorders who acted as normal controls, the mean ( ± SD) GABA level in CSF was 239 ± 76 picomoles/mL. Patients with acute hypoxic encephalopathy showed a mean GABA level in CSF higher than that of the controls, a difference that was statistically significant. In all the other disorders studied, the mean GABA level in CSF was either equal to or lower than that found in the controls. Statistically significant reductions of the GABA level in CSF were seen in patients with Huntington's disease, dementias, cerebellar cortical atrophy, multiple sclerosis, epilepsy, and Parkinson's disease.

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