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July 1980

Neuroleptic Malignant Syndrome

Author Affiliations

From the Department of Neurology (Dr Morris), the Division of Neuropathology (Dr McCormick), and the Department of Internal Medicine (Dr Reinarz), University of Texas Medical Branch, Galveston.

Arch Neurol. 1980;37(7):462-463. doi:10.1001/archneur.1980.00500560092019

• The neuroleptic malignant syndrome is an uncommon, severe illness that consists of fever, muscular rigidity, and stupor. Various neuroleptics have been associated with the disease. A detailed neurological, medical, and neuropathological evaluation of this case was performed. Presumably, the syndrome is secondary to biochemical dysfunction of the basal ganglia and possibly of the hypothalmus.