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September 1980

Comprehensive Viral Immunology of Multiple Sclerosis: I. Clinical, Epidemiological, and CSF Studies

Author Affiliations

From the Neurology (Dr Johnson and Ms Nelson) and Psychiatry (Dr Fein) Services, Veterans Administration Medical Center, and the Departments of Neurology (Dr Johnson and Ms Nelson) and Psychiatry (Dr Fein), University of California, San Francisco; and the Department of Neurology (Dr Likosky), Kaiser Hospital, Santa Clara, Calif.

Arch Neurol. 1980;37(9):537-541. doi:10.1001/archneur.1980.00500580033003

• Epidemiological, clinical, and CSF data were collected on 87 patients with clinically definite multiple sclerosis (MS) and 50 with probable MS. As part of a study of immunologic reactivity to viral antigens, a control group separated into 26 patients with probable inflammatory neural disease and 140 with noninflammatory neural disease was similarly studied. Among the groups with MS, females predominated and both Oriental and Spanish surnamed patients were underrepresented. The spinal cord, optic nerves, and brainstem were the most common sites of initial disease and more than 20% of the patients had only cord symptoms after several years of disease activity. Of several CSF assays used, determination of oligoclonal IgG bands by agarose electrophoresis was most useful diagnostically.

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