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September 1980

HLA-B14 Antigen and Postencephalitic Parkinson's DiseaseTheir Association in an American-Jewish Ethnic Group

Arch Neurol. 1980;37(9):542-544. doi:10.1001/archneur.1980.00500580038004

• Eighteen unrelated American-Jewish patients of Eastern European extraction who had classical postencephalitic Parkinson's disease were typed for HLA-A, HLA-B, and HLA-C antigenic determinants. Compared with 147 ethnically matched controls, the HLA-B14 antigen showed a highly significantly increased frequency in the postencephalitic Parkinson's group (corrected P =.001). This association, though not necessarily reflecting genetic susceptibility to the disease, strongly suggests such a possibility in the pathogenesis of at least this particular variant of parkinsonism.