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September 1980

HLA-B14 Antigen and Postencephalitic Parkinson's DiseaseTheir Association in an American-Jewish Ethnic Group

Author Affiliations

From the Department of Neurology, The Mount Sinai School of Medicine of the City University of New York (Drs Elizan and Yahr), and the Department of Surgery, Tissue Typing Laboratory, UCLA School of Medicine, Los Angeles (Dr Terasaki).

Arch Neurol. 1980;37(9):542-544. doi:10.1001/archneur.1980.00500580038004

• Eighteen unrelated American-Jewish patients of Eastern European extraction who had classical postencephalitic Parkinson's disease were typed for HLA-A, HLA-B, and HLA-C antigenic determinants. Compared with 147 ethnically matched controls, the HLA-B14 antigen showed a highly significantly increased frequency in the postencephalitic Parkinson's group (corrected P =.001). This association, though not necessarily reflecting genetic susceptibility to the disease, strongly suggests such a possibility in the pathogenesis of at least this particular variant of parkinsonism.