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September 1980

Periodic Lateralized Epileptiform Discharges With Preexisting Focal Brain Lesions: Role of Alcohol Withdrawal and Anoxic Encephalopathy

Author Affiliations

From the Department of Neurology, University of California at Irvine Medical Center, Orange, Calif.

Arch Neurol. 1980;37(9):551-554. doi:10.1001/archneur.1980.00500580047006

• Periodic lateralized epileptiform discharges (PLEDs) occurred in three patients during alcohol withdrawal, in two patients with episodes of anoxic ischemia, and in one patient under both conditions. In contrast to previous observations that PLEDs are often associated with acute gross destructive lesions, autopsy results and neurological studies reported here indicated that alcohol withdrawal and/or anoxic ischemia may activate preexisting focal hemispheric lesions to produce PLEDs.

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