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September 1980

Phenytoin and Formation of T Lymphocyte Rosettes

Author Affiliations

From the Departments of Medicine (Dr Neilan) and Neurology (Dr Leppik), University of Minnesota Medical School, Minneapolis. Dr Neilan is now with Temple University Hospital, Philadelphia.

Arch Neurol. 1980;37(9):580-581. doi:10.1001/archneur.1980.00500580076014

• Phenytoin sodium has been associated with the formation of altered T lymphocyte rosettes in vitro. To investigate the clinical relevance of this observation, the formation of T lymphocyte rosettes in nine patients was studied before treatment with phenytoin and after therapeutic concentrations of the drug in plasma were attained. The percentage of total rosette-forming cells found before treatment was not significantly different from the percentage found 24 hours after treatment. Likewise, the percentage of active rosette-forming cells before phenytoin therapy was not significantly less than after therapy. These results suggest that in vivo treatment with phenytoin does not acutely inhibit the formation of T lymphocyte rosettes.

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