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This book is a compilation of symposia papers presented at the Fourth International Congress on Neuromuscular Diseases held in Montreal in September 1978. It consists of eight chapters, four dealing with muscle and the other four with peripheral nerve. Described in the first four chapters are the role of RBCs and muscle membranes in muscle disease, muscle metabolism with reference to thyroid hormones, cyclic nucleotides and calcium, myasthenia gravis and immunobiology of acetylcholine receptors, and developmental disorders of muscle including muscle tissue culture approaches. The other four chapters address the structure, function, metabolism, and cellular interactions of peripheral nerve and neuronal abnormalities in animal models with disease-related, drug-induced conditions. Most of the papers summarize the work carried out in the authors' own laboratories. The authors also review current information on the topic and attempts to formulate working hypotheses. The reader is exposed to a variety of investigative approaches being made