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January 1981

HARD ± E: Warburg's Syndrome-Reply

Author Affiliations

Departments of Ophthalmology and Pathology (Neuropathology) Stanford University School of Medicine Stanford, CA 94305

Arch Neurol. 1981;38(1):66. doi:10.1001/archneur.1981.00510010092025

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In Reply.—  We are grateful to Drs Pagon and Clarren for drawing our attention to the familial cases of a condition resembling "Walker's lissencephaly," the existence of which we were regrettably unaware. It is, however, difficult to judge from the quoted articles whether these cases were identical with ours or only superficially similar. It is a well-known fact in teratology that genetic and environmental factors may produce similar, though not necessarily identical, end results.Obviously, pathogenetic speculations based on morphologic studies alone are bound to be tentative. Nevertheless, the analysis of the lesions in Walker's case and in ours, and also in three similar cases that one of us had the privilege of examining in Dr G. Lyon's laboratory in Brussels, allows of no other interpretation, by present-day criteria, than that of a destructive process in fetal life interfering with neuronal migration and organization. All five cases were sporadic and had no

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