To the Editor.—
Aicardi's syndrome is an easily recognizable entity that is characterized by infantile spasms, agenesis of corpus callosum, chorioretinal lacunae, mental subnormality, vertebral abnormalities, and poor life expectancy.1-3 It occurs only in females. Its cause eludes us. Influenza4 and cytomegalovirus infection5 have been implicated. X-chromosomal-dominant inheritance with manifestation in the heterozygote, the gene being male-lethal,1 or a multiple gene defect,1,6 have been proposed. I studied a case in which corticosteroids may have been a factor.
Report of a Case.—
A 12-month-old girl was admitted to the hospital with multiple craniofacial and vertebral anomalies. She was born to a gravida 5, para 4, abortus 1, 34-year-old nurse who has multiple sclerosis. At eight weeks, the pregnancy was complicated by a relapse of multiple sclerosis, for which 80 units of adrenocorticotropic hormone was given daily for ten days. The rest of the pregnancy was uneventful.