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February 1981

Inflammatory Demyelinating Polyradiculitis in a Patient With Multiple Sclerosis

Author Affiliations

From the Neurological Institute (Drs Lassmann and Budka) and the Neurological Clinic (Dr Schnaberth), University of Vienna.

Arch Neurol. 1981;38(2):99-102. doi:10.1001/archneur.1981.00510020057008

• A case of multiple sclerosis (MS) occurred in which there were recent demyelinated plaques in the CNS, and inflammatory demyelination and remyelination in the peripheral (Schwann cell) portions of the spinal roots. The lesions in the peripheral nervous system (PNS) were characterized by inflammation, primary segmental demyelination, myelin stripping, the occurrence of lipid debriscontaining macrophages in the endoneurium, and remyelination. To our knowledge, this is the first description of simultaneous acute inflammatory demyelination in the CNS and PNS in MS.