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February 1981

Fisher's Syndrome Associated With Epstein-Barr Virus

Author Affiliations

From the Department of Neurology, Illinois Masonic Medical Center, and the Abraham Lincoln School of Medicine, University of Illinois, Chicago.

Arch Neurol. 1981;38(2):134-135. doi:10.1001/archneur.1981.00510020092018

A neurologic syndrome that ineludes acute idiopathic ophthalmoplegia, ataxia, and areflexia was first described by Fisher in 1956.1 A relationship to Guillain-Barré syndrome or acute idiopathic polyradiculoneuropathy has been widely accepted.1-4 To the best of our knowledge, this unusual illness has not been previously reported in association with Epstein-Barr virus infection.

REPORT OF A CASE  A 37-year-old man was admitted to the Illinois Masonic Medical Center, Chicago, on Aug 31, 1978, complaining of diplopia. Two weeks before admission, he had diffuse myalgias and arthralgias that had lasted one day after exposure to a flu-like illness at work. On Aug 26, 1978, he had had pain in the upper orbital and maxillary region bilaterally and right lower facial paresthesias. He had awakened on Aug 27, 1978, with horizontal diplopia. A transient yellow nasal discharge, lightheadedness, and nausea had lasted for two days. He was admitted with diplopia, intermittent right lower facial

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