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May 1981

Erythrocytes in Muscular Dystrophy: Investigation With 31P Nuclear Magnetic Resonance Spectroscopy

Arch Neurol. 1981;38(5):271-274. doi:10.1001/archneur.1981.00510050037003

• Phosphorus 31 nuclear magnetic resonance (31P NMR) signals were recorded from intact human erythrocytes for 16 hours. Total phosphate concentration, which was estimated as the sum of the individual31P signals, was 25% lower in erythrocytes from men with myotonic dystrophy than in control erythrocytes. The inorganic-phosphate fraction contained the highest average phosphate concentration over the 16-hour period, and made the major contribution to the difference in total phosphate between the two groups. This result was not observed in erythrocytes from either women with myotonic dystrophy or patients with Duchenne's dystrophy and may be due to a change in cell membrane permeability to inorganic phosphate, which leads to lower steadystate concentrations of the intracellular phosphates.