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May 1981

Computerized Tomography and Adrenoleukomyeloneuropathy: Differential Appearance in Disease Subtypes

Author Affiliations

From the Departments of Neurology (Dr O'Neill) and Diagnostic Radiology (Dr Forbes), Mayo Clinic and Mayo Foundation, Rochester, Minn.

Arch Neurol. 1981;38(5):293-296. doi:10.1001/archneur.1981.00510050059009

• Five cases of adrenoleukomyeloneuropathy illustrate the differential computerized tomographic (CT) appearance of the disease subtypes adrenoleukodystrophy (ALD) and adrenomyeloneuropathy (AMN). In ALD, the CT is distinctive, reflecting predominant involvement of cerebral white matter. The CT in AMN may be nonspecifically abnormal since the spinal and peripheral white matter are mainly affected. Recognition of an obscure neurologic disease as a leukodystrophy may aid the clinician in designing appropriate biochemical testing and in categorizing the disease process.