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June 1981

CSF Perfusion to Treat Intraventricular Penicillin Toxicity

Author Affiliations

From Veterans Administration Hospital, Minneapolis (Dr Callaghan); Department of Neurological Surgery and Neurology, Henry Ford Hospital, Detroit (Dr Ausman); and Department of Neurosurgery, National Naval Medical Center, Bethesda, Md (Dr Clubb). Dr Callaghan is now at Lilly Laboratory for Clinical Research, Indianapolis.

Arch Neurol. 1981;38(6):390-391. doi:10.1001/archneur.1981.00510060092022

• A shunt infection and meningitis developed in a patient receiving methotrexate intravenously for CNS leukemia. Convulsions and respiratory failure followed the intraventricular administration of 300,000 units of penicillin G potassium. Perfusion with 900 mL of Ringer's lactate removed an amount of penicillin equal to that injected intraventricularly plus some from systemic treatment.