• A shunt infection and meningitis developed in a patient receiving methotrexate intravenously for CNS leukemia. Convulsions and respiratory failure followed the intraventricular administration of 300,000 units of penicillin G potassium. Perfusion with 900 mL of Ringer's lactate removed an amount of penicillin equal to that injected intraventricularly plus some from systemic treatment.
Callaghan JT, Ausman JI, Clubb R. CSF Perfusion to Treat Intraventricular Penicillin Toxicity. Arch Neurol. 1981;38(6):390–391. doi:10.1001/archneur.1981.00510060092022
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