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June 1981

CSF Findings in Primary Lymphoma of the CNS

Author Affiliations

Kaiser Foundation Hospital
USC Medical Center Department of Pathology 2025 Zonal Ave Los Angeles, CA 90033

Arch Neurol. 1981;38(6):397. doi:10.1001/archneur.1981.00510060099027

To the Editor.—  Primary lymphoma of the CNS is an uncommon disease composing less than 1.5% of all intracranial tumors1 and 0.7% of all lymphomas.2 Because of the rarity and the requirement for an aggressive diagnostic procedure, premortem diagnosis is seldom established. This radiosensitive tumor often contains cells productive of immunoglobulin, predominantly monoclonal.The CSF features of three cases diagnosed at the time of autopsy over the past ten years at Los Angeles County-University of Southern California (USC) Medical Center, and a review of pertinent literature,1,3-7 indicate that careful analysis of the CSF may offer a possible means of earlier diagnosis and improve survival in these patients. As indicated in the Table, this assumption is based on the presence of a monomorphic population of cells and a consistently elevated level of CSF protein in a strikingly large proportion of cases. Histologic examination of the tumor infiltrates in