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July 1981

Lipid Analysis in Nerve Biopsy Specimens of Hypertrophic Neuropathy

Author Affiliations

From the Service de Neurologie, CHU Reims, France (Dr Turpin), the Laboratoire de Neuropathologie Charles Foix (Drs Escourolle and Hauw), and the Laboratoire de Neurochimie, Institut Nacional de la Santé et de la Recherche Médicale, Unité 134, Centre Nacional de la Recherche Scientifique, Equipe de Recherche Associée 421 (Drs Pollet and Baumann and Ms Le Saux), Hôpital de la Salpêtrière, Paris.

Arch Neurol. 1981;38(7):436-438. doi:10.1001/archneur.1981.00510070070012

• We performed a lipid analysis on nerve biopsy specimens in two cases of degenerative hypertrophic neuropathy. Quantitative analysis of the major lipid classes, ie, cholesterol, cerebrosides, sulfatides, ethanolamine phospholipids, phosphatidyl-choline, phosphatidyl-serine, phosphatidyl-inositol, sphingomyelin, and gangliosides, were performed. The two cases exhibited extreme decreases in levels of lipids that could be related to the very low myelin content of these nerves. Cholesterol and phospholipid levels were especially reduced. Cerebrosides and sulfatides were not modified in the same proportion, as could have been predicted from the degree of demyelination. This relative glycolipid increase could be due to the very high Schwann cell proliferation.

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